Anna your post to Deni saying cancers caused by RA?/

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Anna your post to Deni saying cancers...

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Stonewoman

Posted Monday, October 29, 2007 9:48 PM

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Anna from your post to Deni:

I wanted to ask Anna who responded to you:
" What side effects of the biologicals are you scared of? Most of the possible cancers are from having untreated RA, not the TNF's."

Anna
do you recall where you read or were told that untreated RA causes cancer?
I'd like to read up on that as I don't recall seeing that before.
Dee
Dee

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LadyeMac

Posted Monday, October 29, 2007 10:09 PM

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Not anna, but I think it's more that people with RA are more susceptible to certain types of cancer. I'm having a pretty yucky day, so short on major links, but here's one I just dug up.

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Annaart

Posted Tuesday, October 30, 2007 5:55 AM

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Here are a couple, though the easiest to read is top one.

http://www.hss.edu/conditions_14612.asp

http://www.medscape.com/viewarticle/538536
http://arthritis.about.com/od/rheumatoidarthritis/a/lymphoma.htm
http://www.sciencedaily.com/releases/2007/06/070614100706.htm
http://ard.bmj.com/cgi/content/extract/64/5/657
http://www.hopkins-arthritis.org/arthritis-news/2007/no-link-between-ra-therapy-and-lymphoma.html

Some of these are about TNF's and cancer risk (NOT), as there has been a lot of recent research.

Anna

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Cindyss

Posted Tuesday, October 30, 2007 9:30 AM

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My rheumy actually told me this when we were discussing the pros and cons of biologics. She thinks it's hard to measure increased risk from the drugs when RA patients in general have a higher risk of some cancers. Cindy

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Annaart

Posted Tuesday, October 30, 2007 8:27 PM

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Cindy, sounds like your doctor is keeping up with all the amazing research coming out.

I posted it on the Deni thread but here it is again.

http://www.hss.edu/conditions_14612.asp

The important paragraph relevant to you>>>
"In order to place this study into perspective, it is important to understand rheumatoid arthritis. It is a severe, systemic, autoimmune disorder that, without optimal treatment, will lead to joint damage that can not be reversed, profound loss of function, and shortened lifespan. The RA inflammation also has a negative, spill-over effect on the rest of the body, and poorly controlled inflammation can lead to the development of premature atherosclerosis, coronary artery disease, osteoporosis, and lymphomas. "

Anna

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Stonewoman

Posted Tuesday, October 30, 2007 11:28 PM

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One important paragraph which shows you can take things out of context:
hss.edu as you cited

"The investigators involved in this study used a research technique called meta-analysis to estimate the risk of cancer and serious infections in rheumatoid arthritis (RA) patients taking either infliximab (Remicade) or adalimumab (Humira). These medications target tumor necrosis factor alpha (TNF), a protein called a cytokine that naturally aids in controlling infections and tumors. However, in certain conditions, like rheumatoid arthritis, TNF can lead to serious joint inflammation and damage. These drugs are monoclonal antibodies that effectively block the effects of TNF and are two of the most effective medications currently available to control the inflammation and joint damage in RA.

Since both cancers and serious infections are relatively rare in patients with rheumatoid arthritis, it takes very large studies to accurately determine if there really is an increased risk associated with anti-TNF therapy."

the other cites you gave are all relating to the same 2006 Swedish study done on 378 patient - with lymphomas - all who were taking TNFs or DMAs - rather inconclusive --
thanks for sharing your knowledge -
no matter which side you come down on, it is not a win/win.
Dee

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Annaart

Posted Wednesday, October 31, 2007 7:32 AM

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There are many many studies that prove (unfortunately) that having RA, esp severe RA and the accompaning inflammation puts untreated patients with a much higher risk of cancer and heart issues. There have been many scary threads recently you can read them too.

Actually, I don't like to be scary because I know many people read without posting when they are new. You can go to any major research hospital and read their research.

Anna

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