Methotrexate delayed nausea

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Charity

Posted Tuesday, September 30, 2008 1:05 PM

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Last Login: Wednesday, October 01, 2008 5:07 PM
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Hi, I was just diagnosed with RA last week and started on Methotrexate Friday evening at a dosage of 12.5 mg. I took the dosage on Friday hoping that if I had a negative reaction it wouldn't be during the work week, but the only reaction I seemed to have this weekend was feeling even more tired. Otherwise I was fine both Saturday and Sunday. Monday I started getting some GERD symptoms and that evening started getting stomach pain during and after supper. I took a couple Tums before bed and it seemed to be okay over night. Then during the night I started with a headache in the back of my head and neck, and now today have extreme nausea and stomach cramps to the point where I want absolutely nothing to eat or drink for fear of not keeping it down.

I'm just curious if others have experienced a delayed response to Methotrexate like this, or if this might be something else. I also had a steroid injection but that was last Wednesday, basically a week ago. I did call in to the doc and am waiting for a call back and was hoping for some feedback from others with RA as I wait for an answer from the doc. Any encouragement or information would be greatly appreciated.

Thanks, Charity

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starshine

Posted Friday, October 03, 2008 2:15 AM

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Last Login: Tuesday, March 02, 2010 3:00 PM
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I have not had nausea from MTX by itself but I did get a bleeding ulcer when I took Ibuprofen while I was also taking the MTX. I think it was mostly from the NSAID's. I have had stomach problems for years since I have been taking arthritis meds. Anyway, I take Prilosec twice a day now and have very few problems. If you haven't gone to RA Connect yet, please go there. It is a very active board and you will get lots more replies. Wink

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Grandpavan

Posted Friday, October 03, 2008 10:55 AM

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Most people take about 1 mg Folic Acid daily when they are on Methotrexate to help relieve the side effects. I don't know if this will help but I don't expect it to hurt. God bless.

Age 82, diagnosed RA 12/2001, married since 1952, 4 sons no daughters, 4 grandsons 1 granddaughter. Doing well on Methotrexate and Remicade.

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kelley bula

Posted Wednesday, January 28, 2009 9:07 AM

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Last Login: Wednesday, January 28, 2009 12:02 PM
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I have been on MTX for about 5 months. I had nausea in the beginning but it went away. This past week in has gotten really bad again. It helps if I eat small amounts frequently. The fatigue is what really gets me for 2-3 days after I take the MTX. If anyone has any other suggestions, I would love to hear them. By the way, I am on MTX 15mg, Arava 20mg, Plaquenil 200mg & Mobic 15mg. Unfortunately, I have only had a small improvement in my symptoms-it is very discouraging!

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Grandpavan

Posted Thursday, January 29, 2009 12:25 PM

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Last Login: Today @ 12:35 AM
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I do well on the pills but I have heard that many have fewer side effects by using injections instead of pills. Perhaps that is worth a try. Also the Rheumatoid Arthritis forum is much more active and you may get more ideas by posting there also. You don't have to have RA to post there. I hope you find some way to get relief. God bless.

Age 82, diagnosed RA 12/2001, married since 1952, 4 sons no daughters, 4 grandsons 1 granddaughter. Doing well on Methotrexate and Remicade.

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