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Methotrexate Reaction? Expand / Collapse
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Wendy Mom
Posted Sunday, April 26, 2009 9:52 PM


 

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My son, who is 4, has been diagnosed with polyarticular JRA.  He was diagnosed in December, we began methotrexate in March.  He has had 7 doses so far, all have been administered by me on Friday nights.  He spiked a fever at about 6 tonight (Sunday) and pretty promptly after, vomited.  I have heard nausea and vomitting are normal reactions, but is this to be expected 48 hours later?  After vomitting, he took a shower and now feels much better and his fever is down from 103.5 to 100.5.  Is fever ever a common side effect?  Could it be related to the vomitting?  Should I be worried about systemic JRA onset?  Just looking to see if anyone out there has had a similar reaction or has knowledge on this.  (Is it bad to be hoping for the simple stomach flu after all we've been through in the past 5 months?)
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Suzanne321
Posted Monday, April 27, 2009 11:14 AM


 

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Wendy Reitz (4/26/2009)
(Is it bad to be hoping for the simple stomach flu after all we've been through in the past 5 months?)


I know exactly what you mean by that! My daughter's ped and I once practically danced around the exam room when she had strep!

My daughter always felt the worst about 48 hours after her mtx, but since your son also has a fever, that makes it sound more like a stomach flu to me. I hope he is feeling better today!
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Mom to Alex
Posted Tuesday, April 28, 2009 2:31 PM


 

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Wendy Mom (4/26/2009)
(Is it bad to be hoping for the simple stomach flu after all we've been through in the past 5 months?)

Well I am completely new to all this...but no I don't think it's bad at all.  We start methotrxate on Saturday night...

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Wanda Vanhorn
Posted Sunday, May 03, 2009 12:57 AM


 

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My 7 yr old has been taking Methotraxate for 3 yrs now. She complains all the time about stomachs. She takes it orally and a very small dose, larger doses give her mouth sores.

I would like to welcome you both!

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Mom of Hannah
Posted Monday, June 08, 2009 1:54 PM


 

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Do you think it is better to give the methotrexate in the evening or morning. Or does it not matter? My daughter takes MTX orally once a week. I always give it to her in the morning and she seems cranky that day and the next.  Just trying to figure out ways to make things easier for her.

Thanks! 

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Mom to Alex
Posted Monday, June 08, 2009 2:24 PM


 

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My son gets the MTX injection once per week and we do it Saturday night...he is sleepy for up to 48 hours but no other issues with it (so far...thank God!)  Maybe if you gave it at night she would be able to sleep through the worst of it?  I'm not familiar with the oral side effects other than it seems to have more gastro side effects.

Good luck!

Karen and Alex, 5, poly (04/09)...and big Sis 'Yaya', 7

 

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Mom of Hannah
Posted Tuesday, June 09, 2009 9:30 AM


 

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thanks! I will trying giving her the MTX at night and hopefully she will sleep thru most of the crankiness.  She may have to start getting the MTX by injection - do you give your son his shot while he sleeps?   I'm very nervous about giving my daughter an injection (I'm needle phobic) and I'm sure she wouldn't like it either!!

Mom to Hannah

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Mom to Alex
Posted Tuesday, June 09, 2009 11:10 AM


 

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Mom of Hannah (6/9/2009)
thanks! I will trying giving her the MTX at night and hopefully she will sleep thru most of the crankiness.  She may have to start getting the MTX by injection - do you give your son his shot while he sleeps?   I'm very nervous about giving my daughter an injection (I'm needle phobic) and I'm sure she wouldn't like it either!!

Mom to Hannah

Hi...my son just got his sixth injection on Saturday night and it was the first we did while he was sleeping.  I posted about it in another thread on here I started on Sunday...titled something like 'HAha only you all would get this.'  Our rheumy initially suggested doing this but I was hesitant...which I shouldn't have been.

Good luck and all the best!

Karen and Alex, 5, poly (04/09) and Big Sis 'Yaya', 7

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Wendy Mom
Posted Tuesday, June 09, 2009 6:16 PM


 

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The needle gets a bit easier over time, but I still don't love it.  My son also has celiac disease and his absorbtion is an issue so we must use injections.  If you have to go this route, be sure to ask for the smallest gauge needle.  I think we use 29 now, but started with much larger (24 or 27- it goes backwards.)

He still throws up periodically, 48-72 hours later, but we are all getting a bit used to it. After he throws up, he feels much better and we get on with our day.  I don't think he knows it's a reaction to the mxt, and I don't know when I'll tell him.

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Vicky
Posted Tuesday, June 09, 2009 6:35 PM


 

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i use the 31 insulin needles for brianna's injections.  what a difference!  they're tiny.  i use the walgreens brand super fine II...and the ethyl chloride spray really helps.  even for blood draws...good luck!
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Mom of Hannah
Posted Wednesday, June 10, 2009 9:32 AM


 

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thank you all for the information. Having some knowledge makes things seem less scary and overwelming.  I like our rheumatologist but reading these message boards has given me so much useful information. I wish I would have started reading them when my daughter was diagnosed a year and a half ago.   I don't want my child or anyone else's to have arthritis but knowing people are going thru the same thing some how helped me - the first time I read thru the message board I actually cried.

Thanks again - the info is much appreciated !!

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Wendy Mom
Posted Wednesday, June 10, 2009 10:43 PM


 

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We like our rheum too, but he has a huge caseload, as I think is the case of most pediatric rheums.  Sometimes these message boards have info that the rheum doesn't hav eenough time to consider.

I'm glad you're feeling better. This is the first message board I have ever joined, so I know how you feel.

Thanks and good luck!

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