Enbryl safety

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Sunni Ashforth

Posted Tuesday, August 04, 2009 4:53 PM

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Last Login: Wednesday, August 05, 2009 10:04 PM
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We just found a new FDA warning out on Enbryl stating that it increases the risk of cancer in patients who are on it for more than 2 years. Google this and ask your doctor at the next appt. We are going on Friday to my daughter's JRA dr. at Duke Hospital. She has polyarticular JRA and has been on Enbryl since February when she was diagnosed. She has been doing well on Enbryl and her symptoms are better, but we are not happy with this new announcement!! I will keep you all updated on what we find out.

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Suzanne321

Posted Tuesday, August 04, 2009 5:15 PM

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Last Login: Tuesday, November 03, 2009 2:54 PM
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http://finance.yahoo.com/news/FDA-Arthritis-drugs-pose-apf-3499832425.html?x=0&sec=topStories&pos=4&asset=&ccode=

FDA: Arthritis drugs pose cancer risk to children
FDA bolsters warnings on blockbuster arthritis drugs due to cancer risk in children

* By Matthew Perrone, AP Business Writer
* On Tuesday August 4, 2009, 3:55 pm EDT

o
Buzz up! 2
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WASHINGTON (AP) -- Federal regulators on Tuesday added stronger warnings to a group of best-selling drugs used to treat arthritis and other inflammatory diseases, saying they can increase the risk of cancer in children and adolescents.

After more than a year of review, Food and Drug Administration scientists said the drugs appear to increase the risk of cancer after they are used beyond 2 1/2 years. The agency studied several dozen reports of cancer in children taking the drugs, some of which were fatal. Half of the cases were lymphomas, a cancer that attacks the immune system.

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Mom to Alex

Posted Thursday, August 06, 2009 11:00 AM

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Last Login: Sunday, November 15, 2009 7:33 PM
Posts: 86, Visits: 164

Here's some more information...while still scary, I really don't think there is anything 'new' here...and lots of information still unknown and/or unclear. My son is starting Enbrel this week...

Prayers for all of us using there drugs for our kiddos.

http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm174474.htm

Karen and Alex, 6, poly (04/09)

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Suzanne321

Posted Thursday, August 06, 2009 1:22 PM

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Last Login: Tuesday, November 03, 2009 2:54 PM
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This is 'new':

"After more than a year of review, Food and Drug Administration scientists said the drugs appear to increase the risk of cancer after they are used beyond 2 1/2 years."

I've never seen a time frame until this review.

Post #4223359

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Mom to Alex

Posted Thursday, August 06, 2009 2:46 PM

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Last Login: Sunday, November 15, 2009 7:33 PM
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OK...I am still very new to this whole world.

I am trying to find the actual study...anyone know how to get it?

Post #4223401

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Suzanne321

Posted Thursday, August 06, 2009 3:03 PM

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Last Login: Tuesday, November 03, 2009 2:54 PM
Posts: 870, Visits: 182

My understanding is that this was review - so they compiled existing data and made a conclusion. The link you posted is the one I found with the most info so far.

There may be a 'full report' on the FDA site somewhere, but I think that link is pretty thorough.

I'm sorry this news had to break at this time for your situation, but you are right that most of it has been known for awhile. I think the '2 1/2 years' is good information - you sort of have that long before you seriously, seriously have to decide if the risk is worth the benefit. By then, you would have clearly experienced what the benefits are.

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